Tuskaloosa (Tuskalusa, Tastaluca, Tuskaluza) (died 1540) was a paramount chief of a Mississippian chiefdom in what is now the U.S. state of Alabama. His people were possibly ancestors to the several southern Native American confederacies (the Choctaw and Creek peoples) who later emerged in the region.

The modern city of Tuscaloosa, Alabama, is named for him.

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